منابع مشابه
Defining a gene promoter methylation signature in sputum for lung cancer risk assessment.
PURPOSE To evaluate the methylation state of 31 genes in sputum as biomarkers in an expanded nested, case-control study from the Colorado cohort, and to assess the replication of results from the most promising genes in an independent case-control study of asymptomatic patients with stage I lung cancer from New Mexico. EXPERIMENTAL DESIGN Cases and controls from Colorado and New Mexico were i...
متن کاملExpression of DMBT1, a candidate tumor suppressor gene, is frequently lost in lung cancer.
DMBT1 is a candidate tumor suppressor gene located at 10q25.3-26.1. Homozygous deletion of the gene was found in a subset of medulloblastoma and glioblastoma multiforme; lack of expression was noted in the majority of these tumors. In adult tissues, DMBT1 is highly expressed only in lung and small intestine tissues, indicating its important role in these organs. By analyzing lung cancer cell li...
متن کاملMicroarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention.
Retinoids, natural and synthetic derivatives of vitamin A, are active in cancer therapy and chemoprevention. We reported previously that all-trans-retinoic acid (RA) treatment prevented carcinogen-induced transformation of immortalized human bronchial epithelial (HBE) cells. To identify cancer chemopreventive mechanisms, immortalized (BEAS-2B), carcinogen-transformed (BEAS-2B(NNK)), and RA-chem...
متن کاملFunctional Characterization of CLPTM1L as a Lung Cancer Risk Candidate Gene in the 5p15.33 Locus
Cleft Lip and Palate Transmembrane Protein 1-Like (CLPTM1L), resides in a region of chromosome 5 for which copy number gain has been found to be the most frequent genetic event in the early stages of non-small cell lung cancer (NSCLC). This locus has been found by multiple genome wide association studies to be associated with lung cancer in both smokers and non-smokers. CLPTM1L has been identif...
متن کاملA candidate tumor suppressor gene, H37, from the human lung cancer tumor suppressor locus 3p21.3.
Frequent allelic loss and homozygous deletions within chromosome 3p in human lung cancers have suggested that the 3p21.3 (370-kb) region contains a critical tumor suppressor gene(s) (TSG). With the exact identity/characteristics of such a gene(s) still unconfirmed, a lack of inactivating structural mutations in the expressed genes contained within this region may indicate that the 3p TSG(s) do ...
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ژورنال
عنوان ژورنال: JNCI: Journal of the National Cancer Institute
سال: 2008
ISSN: 0027-8874,1460-2105
DOI: 10.1093/jnci/djn381